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The principal cytochrome P450 isoenzyme involved appears to become CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Close to 85% of the oral dose seems during the urine within 24 hrs of administration, most because the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity information.H